Mineralocorticoid receptor antagonists: new extended roles in cardio- and nephroprotection
نویسندگان
چکیده
منابع مشابه
Mineralocorticoid receptor antagonists: emerging roles in cardiovascular medicine
Spironolactone was first developed over 50 years ago as a potent mineralocorticoid receptor (MR) antagonist with undesirable side effects; it was followed a decade ago by eplerenone, which is less potent but much more MR-specific. From a marginal role as a potassium-sparing diuretic, spironolactone was shown to be an extraordinarily effective adjunctive agent in the treatment of progressive hea...
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Mineralocorticoid receptor (MR) antagonists are known to have beneficial effects in patients with cardiovascular disease without renal failure. However, there have been few published studies on the effectiveness of MR antagonists in dialysis patients, and most of the studies were small-sized. The present review focuses on the effectiveness of MR antagonists and the risk of hyperkalemia in dialy...
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The cDNA of the mineralocorticoid receptor (MR) was cloned 30 years ago, in 1987. At that time, spirolactone, the first generation of synthetic steroid-based MR antagonists (MRAs), which was identified in preclinical in vivo models, had already been in clinical use for 30 years. Subsequent decades of research and development by Searle & Co., Ciba-Geigy, Roussel Uclaf and Schering AG toward iden...
متن کاملMineralocorticoid receptor antagonists and renal involvement in primary aldosteronism: opening of a new era.
Primary aldosteronism (PA) is one of the commonest forms of curable hypertension, and use of the plasma aldosterone-to-renin ratio as a screening test has led to a more efficient identification of this condition. Both animal and human studies have indicated that PA is associated with a variety of cardiovascular and renal complications that reflect the capability of elevated aldosterone to induc...
متن کاملReconsidering the roles of the mineralocorticoid receptor.
Translational research is usually taken to mean the application of laboratory discovery to clinical practice. Like languages or enzymes, however, translation is a 2-way street, and in the field of aldosterone and mineralocorticoid receptors (MR), there are a number of examples where clinical studies have prompted reconsideration of the basic biology. For example, in essential hypertensive subje...
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ژورنال
عنوان ژورنال: Medical Council
سال: 2018
ISSN: 2079-701X
DOI: 10.21518/2079-701x-2018-5-58-63